Pharmacokinetics/ADME
Pharmacokinetics
Biodistribution (case study; case study)
CYPs Inhibition/Induction
Cytotoxicity
Drug Solubility
In-vitro Intrinsic Clearance
Membrane Permeability
Metabolic Stability
Protein Binding
Bioanalytical Method Development and Validation
Quantitative analysis of proteins in complex matrices (method setup and validation, analysis) using immunoenzymatic assays.
Quantitative analysis of nucleic acids (case study, case study) in complex matrices (method setup and validation, analysis) using Real time PCR.
LC-MS/MS for quantitative analysis of small molecules and peptides (case study) (method setup and validation, analysis) using SRM or MRM mode.
PK/TK and Biomarkers analyses, if required by regulatory authorities, can be performed according to GLP and relevant ICH, EMEA, and FDA guidelines and routinely audited by our Quality Assurance Group.
